diff --git a/Makefile b/Makefile
index c530eb8..dd11a9f 100644
--- a/Makefile
+++ b/Makefile
@@ -40,6 +40,7 @@ ALLOCA_O=alloca86.o alloca86-bt.o
 else
 ifeq ($(ARCH),x86-64)
 NATIVE_DEFINES=-DTCC_TARGET_X86_64
+NATIVE_DEFINES+=$(if $(wildcard /lib64/ld-linux-x86-64.so.2),-DTCC_TARGET_X86_64_CENTOS)
 LIBTCC1=libtcc1.a
 BCHECK_O=
 ALLOCA_O=alloca86_64.o
diff --git a/libtcc.c b/libtcc.c
index 520abfd..2f23fe6 100644
--- a/libtcc.c
+++ b/libtcc.c
@@ -944,9 +944,15 @@ LIBTCCAPI TCCState *tcc_new(void)
     
 #ifndef TCC_TARGET_PE
     /* default library paths */
-    tcc_add_library_path(s, CONFIG_SYSROOT "/usr/local/lib");
+# if defined(TCC_TARGET_X86_64_CENTOS)
+    tcc_add_library_path(s, CONFIG_SYSROOT "/usr/lib64");
+    tcc_add_library_path(s, CONFIG_SYSROOT "/lib64");
+    tcc_add_library_path(s, CONFIG_SYSROOT "/usr/local/lib64");
+# else
     tcc_add_library_path(s, CONFIG_SYSROOT "/usr/lib");
     tcc_add_library_path(s, CONFIG_SYSROOT "/lib");
+    tcc_add_library_path(s, CONFIG_SYSROOT "/usr/local/lib");
+# endif
 #endif
 
     /* no section zero */
diff --git a/tcc.h b/tcc.h
index 156bdd0..ef0bb78 100644
--- a/tcc.h
+++ b/tcc.h
@@ -136,7 +136,11 @@ typedef int BOOL;
 
 /* path to find crt1.o, crti.o and crtn.o. Only needed when generating
    executables or dlls */
-#define CONFIG_TCC_CRT_PREFIX CONFIG_SYSROOT "/usr/lib"
+#if defined(TCC_TARGET_X86_64_CENTOS)
+# define CONFIG_TCC_CRT_PREFIX CONFIG_SYSROOT "/usr/lib64"
+#else
+# define CONFIG_TCC_CRT_PREFIX CONFIG_SYSROOT "/usr/lib"
+#endif
 
 #define INCLUDE_STACK_SIZE  32
 #define IFDEF_STACK_SIZE    64
diff --git a/tccelf.c b/tccelf.c
index 2d884d2..f262ac5 100644
--- a/tccelf.c
+++ b/tccelf.c
@@ -1307,7 +1307,11 @@ static const char elf_interp[] = "/libexec/ld-elf.so.1";
 #elif defined TCC_ARM_EABI
 static const char elf_interp[] = "/lib/ld-linux.so.3";
 #elif defined(TCC_TARGET_X86_64)
+# if defined(TCC_TARGET_X86_64_CENTOS)
+static const char elf_interp[] = "/lib64/ld-linux-x86-64.so.2";
+# else
 static const char elf_interp[] = "/lib/ld-linux-x86-64.so.2";
+# endif /* TCC_TARGET_X86_64_CENTOS */
 #elif defined(TCC_UCLIBC)
 static const char elf_interp[] = "/lib/ld-uClibc.so.0";
 #else