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When doing device assignment of a physical device, MSI-X can be enabled with no vectors enabled and this sets the IRQ index to VFIO_PCI_MSIX_IRQ_INDEX. However, when MSI-X is disabled, the IRQ index is left untouched if no vectors are in use. Then, when INTx is enabled, the IRQ index value is considered incompatible (set to MSI-X) and VFIO_DEVICE_SET_IRQS fails. QEMU complains with : qemu-system-x86_64: vfio 0000:08:00.0: Failed to set up TRIGGER eventfd signaling for interrupt INTX-0: VFIO_DEVICE_SET_IRQS failure: Invalid argument To avoid that, unconditionaly clear the IRQ index when MSI-X is disabled. Buglink: https://issues.redhat.com/browse/RHEL-21293 Fixes: 5ebffa4e87e7 ("vfio/pci: use an invalid fd to enable MSI-X") Cc: Jing Liu <jing2.liu@intel.com> Cc: Alex Williamson <alex.williamson@redhat.com> Reviewed-by: Alex Williamson <alex.williamson@redhat.com> Signed-off-by: Cédric Le Goater <clg@redhat.com>