diff --git a/hw/nvme/ctrl.c b/hw/nvme/ctrl.c
index dc0e7b0030..2f247a9275 100644
--- a/hw/nvme/ctrl.c
+++ b/hw/nvme/ctrl.c
@@ -3893,6 +3893,10 @@ static uint16_t nvme_io_cmd(NvmeCtrl *n, NvmeRequest *req)
         return ns->status;
     }
 
+    if (NVME_CMD_FLAGS_FUSE(req->cmd.flags)) {
+        return NVME_INVALID_FIELD;
+    }
+
     req->ns = ns;
 
     switch (req->cmd.opcode) {
@@ -5475,6 +5479,10 @@ static uint16_t nvme_admin_cmd(NvmeCtrl *n, NvmeRequest *req)
         return NVME_INVALID_FIELD | NVME_DNR;
     }
 
+    if (NVME_CMD_FLAGS_FUSE(req->cmd.flags)) {
+        return NVME_INVALID_FIELD;
+    }
+
     switch (req->cmd.opcode) {
     case NVME_ADM_CMD_DELETE_SQ:
         return nvme_del_sq(n, req);