diff --git a/tcg/s390x/tcg-target-con-set.h b/tcg/s390x/tcg-target-con-set.h
index 33a82e3286..b1a89a88ba 100644
--- a/tcg/s390x/tcg-target-con-set.h
+++ b/tcg/s390x/tcg-target-con-set.h
@@ -31,6 +31,7 @@ C_O1_I3(v, v, v, v)
 C_O1_I4(r, r, ri, r, 0)
 C_O1_I4(r, r, ri, rI, 0)
 C_O2_I2(o, m, 0, r)
+C_O2_I2(o, m, r, r)
 C_O2_I3(o, m, 0, 1, r)
 C_O2_I4(r, r, 0, 1, rA, r)
 C_O2_I4(r, r, 0, 1, ri, r)
diff --git a/tcg/s390x/tcg-target.c.inc b/tcg/s390x/tcg-target.c.inc
index 9634126ed1..871fcb7683 100644
--- a/tcg/s390x/tcg-target.c.inc
+++ b/tcg/s390x/tcg-target.c.inc
@@ -175,6 +175,7 @@ typedef enum S390Opcode {
     RRE_SLBGR   = 0xb989,
     RRE_XGR     = 0xb982,
 
+    RRFa_MGRK   = 0xb9ec,
     RRFa_MSRKC  = 0xb9fd,
     RRFa_MSGRKC = 0xb9ed,
     RRFa_NRK    = 0xb9f4,
@@ -2319,6 +2320,11 @@ static inline void tcg_out_op(TCGContext *s, TCGOpcode opc,
         tcg_debug_assert(args[0] == args[1] + 1);
         tcg_out_insn(s, RRE, MLGR, args[1], args[3]);
         break;
+    case INDEX_op_muls2_i64:
+        tcg_debug_assert((args[1] & 1) == 0);
+        tcg_debug_assert(args[0] == args[1] + 1);
+        tcg_out_insn(s, RRFa, MGRK, args[1], args[2], args[3]);
+        break;
 
     case INDEX_op_shl_i64:
         op = RSY_SLLG;
@@ -3009,6 +3015,8 @@ static TCGConstraintSetIndex tcg_target_op_def(TCGOpcode op)
 
     case INDEX_op_mulu2_i64:
         return C_O2_I2(o, m, 0, r);
+    case INDEX_op_muls2_i64:
+        return C_O2_I2(o, m, r, r);
 
     case INDEX_op_add2_i32:
     case INDEX_op_sub2_i32:
diff --git a/tcg/s390x/tcg-target.h b/tcg/s390x/tcg-target.h
index 1fb7b8fb1d..03ce11a34a 100644
--- a/tcg/s390x/tcg-target.h
+++ b/tcg/s390x/tcg-target.h
@@ -136,7 +136,7 @@ extern uint64_t s390_facilities[3];
 #define TCG_TARGET_HAS_add2_i64       1
 #define TCG_TARGET_HAS_sub2_i64       1
 #define TCG_TARGET_HAS_mulu2_i64      1
-#define TCG_TARGET_HAS_muls2_i64      0
+#define TCG_TARGET_HAS_muls2_i64      HAVE_FACILITY(MISC_INSN_EXT2)
 #define TCG_TARGET_HAS_muluh_i64      0
 #define TCG_TARGET_HAS_mulsh_i64      0