diff --git a/target/s390x/helper.h b/target/s390x/helper.h
index 23b37af1e4..c788fc1b7f 100644
--- a/target/s390x/helper.h
+++ b/target/s390x/helper.h
@@ -290,6 +290,8 @@ DEF_HELPER_FLAGS_6(gvec_vfms64, TCG_CALL_NO_WG, void, ptr, cptr, cptr, cptr, env
 DEF_HELPER_FLAGS_6(gvec_vfms64s, TCG_CALL_NO_WG, void, ptr, cptr, cptr, cptr, env, i32)
 DEF_HELPER_FLAGS_4(gvec_vfsq64, TCG_CALL_NO_WG, void, ptr, cptr, env, i32)
 DEF_HELPER_FLAGS_4(gvec_vfsq64s, TCG_CALL_NO_WG, void, ptr, cptr, env, i32)
+DEF_HELPER_FLAGS_5(gvec_vfs64, TCG_CALL_NO_WG, void, ptr, cptr, cptr, env, i32)
+DEF_HELPER_FLAGS_5(gvec_vfs64s, TCG_CALL_NO_WG, void, ptr, cptr, cptr, env, i32)
 
 #ifndef CONFIG_USER_ONLY
 DEF_HELPER_3(servc, i32, env, i64, i64)
diff --git a/target/s390x/insn-data.def b/target/s390x/insn-data.def
index 354252d57c..4426f40250 100644
--- a/target/s390x/insn-data.def
+++ b/target/s390x/insn-data.def
@@ -1244,6 +1244,8 @@
     F(0xe7cc, VFPSO,   VRR_a, V,   0, 0, 0, 0, vfpso, 0, IF_VEC)
 /* VECTOR FP SQUARE ROOT */
     F(0xe7ce, VFSQ,    VRR_a, V,   0, 0, 0, 0, vfsq, 0, IF_VEC)
+/* VECTOR FP SUBTRACT */
+    F(0xe7e2, VFS,     VRR_c, V,   0, 0, 0, 0, vfa, 0, IF_VEC)
 
 #ifndef CONFIG_USER_ONLY
 /* COMPARE AND SWAP AND PURGE */
diff --git a/target/s390x/translate_vx.inc.c b/target/s390x/translate_vx.inc.c
index 75f3596c4b..c0a19aa9f3 100644
--- a/target/s390x/translate_vx.inc.c
+++ b/target/s390x/translate_vx.inc.c
@@ -2566,6 +2566,9 @@ static DisasJumpType op_vfa(DisasContext *s, DisasOps *o)
     case 0xe7:
         fn = se ? gen_helper_gvec_vfm64s : gen_helper_gvec_vfm64;
         break;
+    case 0xe2:
+        fn = se ? gen_helper_gvec_vfs64s : gen_helper_gvec_vfs64;
+        break;
     default:
         g_assert_not_reached();
     }
diff --git a/target/s390x/vec_fpu_helper.c b/target/s390x/vec_fpu_helper.c
index 18773eb559..ccdc975628 100644
--- a/target/s390x/vec_fpu_helper.c
+++ b/target/s390x/vec_fpu_helper.c
@@ -569,3 +569,20 @@ void HELPER(gvec_vfsq64s)(void *v1, const void *v2, CPUS390XState *env,
 {
     vop64_2(v1, v2, env, true, false, 0, vfsq64, GETPC());
 }
+
+static uint64_t vfs64(uint64_t a, uint64_t b, float_status *s)
+{
+    return float64_sub(a, b, s);
+}
+
+void HELPER(gvec_vfs64)(void *v1, const void *v2, const void *v3,
+                        CPUS390XState *env, uint32_t desc)
+{
+    vop64_3(v1, v2, v3, env, false, vfs64, GETPC());
+}
+
+void HELPER(gvec_vfs64s)(void *v1, const void *v2, const void *v3,
+                         CPUS390XState *env, uint32_t desc)
+{
+    vop64_3(v1, v2, v3, env, true, vfs64, GETPC());
+}