diff --git a/hw/ssi/xlnx-versal-ospi.c b/hw/ssi/xlnx-versal-ospi.c
index c7b95b1f37..c479138ec1 100644
--- a/hw/ssi/xlnx-versal-ospi.c
+++ b/hw/ssi/xlnx-versal-ospi.c
@@ -1772,6 +1772,12 @@ static void xlnx_versal_ospi_init(Object *obj)
     memory_region_init_io(&s->iomem_dac, obj, &ospi_dac_ops, s,
                           TYPE_XILINX_VERSAL_OSPI "-dac", 0x20000000);
     sysbus_init_mmio(sbd, &s->iomem_dac);
+    /*
+     * The OSPI DMA reads flash data through the OSPI linear address space (the
+     * iomem_dac region), because of this the reentrancy guard needs to be
+     * disabled.
+     */
+    s->iomem_dac.disable_reentrancy_guard = true;
 
     sysbus_init_irq(sbd, &s->irq);