diff --git a/misc/syntax/Syntax.in b/misc/syntax/Syntax.in
index f2be70720..53d8c6a46 100644
--- a/misc/syntax/Syntax.in
+++ b/misc/syntax/Syntax.in
@@ -40,7 +40,10 @@ include lsm.syntax
 file .\*(bash(_completion|rc)|profile|\\.(sh|bash(rc|_(completion|profile|log(in|out)|aliases|exports|history))|profile|zlog(in|out)|zprofile|zsh(env|rc)))$ Shell\sScript ^#!\s\*/(.\*/|usr/bin/env\s)([a-z]?|ba|pdk)sh
 include sh.syntax
 
-file .\* OpenRC\sRunscript\sFile ^#!\s\*/sbin/openrc-run
+# Since openrc scripts have no extension "by definition", use an empty pattern
+# that doesn't match any file name, and therefore only the shebang is used to detect
+# syntax highlighting rules (see tickets #4246 and #4252 for details).
+file ^$ OpenRC\sRunscript\sFile ^#!\s\*/sbin/openrc-run
 include sh.syntax
 
 file ..\*\\.((?i:ini)|desktop|busname|(auto)?mount|net(dev|work)|link|path|service|slice|socket|swap|target|timer)$ INI-based\sFile