diff -rupN a/numpy/core/include/numpy/npy_cpu.h b/numpy/core/include/numpy/npy_cpu.h
--- a/numpy/core/include/numpy/npy_cpu.h	2023-03-15 22:49:28.138409188 +0300
+++ b/numpy/core/include/numpy/npy_cpu.h	2023-03-15 22:56:24.855588754 +0300
@@ -20,6 +20,7 @@
  *              NPY_CPU_RISCV64
  *              NPY_CPU_LOONGARCH
  *              NPY_CPU_WASM
+ *              NPY_CPU_E2K
  */
 #ifndef NUMPY_CORE_INCLUDE_NUMPY_NPY_CPU_H_
 #define NUMPY_CORE_INCLUDE_NUMPY_NPY_CPU_H_
@@ -109,6 +110,8 @@
 #elif defined(__EMSCRIPTEN__)
     /* __EMSCRIPTEN__ is defined by emscripten: an LLVM-to-Web compiler */
     #define NPY_CPU_WASM
+#elif defined(__e2k__)
+    #define NPY_CPU_E2K
 #else
     #error Unknown CPU, please report this to numpy maintainers with \
     information about your platform (OS, CPU and compiler)
diff -rupN a/numpy/core/include/numpy/npy_endian.h b/numpy/core/include/numpy/npy_endian.h
--- a/numpy/core/include/numpy/npy_endian.h	2023-03-15 22:49:49.193212863 +0300
+++ b/numpy/core/include/numpy/npy_endian.h	2023-03-15 22:57:35.768096981 +0300
@@ -50,7 +50,8 @@
             || defined(NPY_CPU_ARCEL)         \
             || defined(NPY_CPU_RISCV64)       \
             || defined(NPY_CPU_LOONGARCH)     \
-            || defined(NPY_CPU_WASM)
+            || defined(NPY_CPU_WASM)          \
+            || defined(NPY_CPU_E2K)
         #define NPY_BYTE_ORDER NPY_LITTLE_ENDIAN
 
     #elif defined(NPY_CPU_PPC)                \